ENDOG and Parkinson disease: For example, expression of the Parkinson's disease (PD)-related protein α-synuclein in yeast leads to disturbance of Rab1p-mediated ER-to-Golgi trafficking and ER stress (Cooper et al.2006), as well as reduced vacuolar proteolytic function (Aufschnaiter et al.2017) and results in cytotoxicity, which involves the Golgi-localized Ca2+ transporter, Pmr1p, and the mitochondrial nuclease, Nuc1p (yeast homolog of EndoG).