Different yeast-expressing proteotoxic proteins, namely α-synuclein, transactive response DNA-binding protein 43 (TDP-43, involved in frontotemporal dementia) and htt-72Q (the mutant form of huntingtin causing Huntington's disease) revealed 8-hydroxyquinolines (8-OHQs) as potential lead substances against neurodegenerative diseases. This evidence concerns the gene HTT and Huntington disease.