However, a recent study by Schick et al did not find significant difference in the plasma levels of C3a, Ba, sC5b-9, CFH, CFI between AMD patients and age-matched controls, but the aqueous levels of C3a and Ba were significantly higher in AMD patients [42], suggesting that uncontrolled local but not systemic complement activation may play an important role in AMD pathogenesis. Here, C3 is linked to age-related macular degeneration.