KDR and neoplasm: The heightened VEGFR2 is anchored on the plasma membrane (PM) in EC-iDKO mice, leading to augmented VEGFR2 signaling and tumor angiogenesis.[20] Because these vessels are not functional, the tumors are actually much smaller.[20] A domain mapping experiment suggests that the UIM in epsins is critical for regulating the epsin-VEGFR2 interaction, and that loss of UIM in epsin 1 blocks the interaction between epsin and VEGFR2.[20]