Molecular modeling revealed that the UIM peptide forms a helical structure known as yeast Vps27-UIM.[19] To ensure exclusive delivery of the UIM peptide to tumor vasculature, a tumor EC-homing peptide, iRGD, was conjugated to the N-terminus of the UIM peptide.[23] iRGD binds to αvβ3 or αvβ5 integrin, then to neuropilin, and thus can be specifically internalized into TECs.[24,25]. The gene discussed is HGS; the disease is neoplasm.