HGS and neoplasm: This conclusion has been further confirmed by in vitro and in vivo experiments, as well as by the specific designed peptide binding assay using isolated tumor ECs.[19] Interestingly, the Hrs-UIM or Eps15-UIM peptide does not show promising therapeutic efficacy in animal tumor models,[19] further suggesting the specificity of the epsin-UIM peptide to VEGFR2 KD binding.