In this study, we found that oral EBV loads in NPC patients were not only lower than that in healthy individuals; but reversely associated with anti‐VCA‐IgA and anti‐EA‐IgA, 2 antibodies against EBV lytic period, suggesting a simultaneous emergence of enhanced innate immunity response to EBV lytic period and reduced local EBV activation in oral cavity. Here, CD79A is linked to nasopharyngeal carcinoma.