WWOX, a gene bearing the WW domain, straddles a very common chromosomal fragile site (FRA16D) which is known to be altered in various types of cancers.27 Addressing the vital role of angiogenesis is important in the process of tumorigenesis and the metastasis or recurrence in HCC 28 . The gene discussed is WWOX; the disease is hepatocellular carcinoma.