Many studies have shown that the WWOX gene may play a critical role in anti‐angiogenesis by interacting with bcl‐2, c‐Jun, and VEGF.13, 14, 15 In addition, to our knowledge, recent studies in HCC frequently focused on the relationship of genetic variations in WWOX,16 yet, only limited studies linked the prognosis of HCC to WWOX expression levels.17 This evidence concerns the gene BCL2 and hepatocellular carcinoma.