Increasing evidences have indicated that aberrant expression of oncogenes or tumor suppressors are widely recognized as important factors in the carcinogenesis and progression of human carcinomas.25, 26 In our study, we found that that WWOX mRNA and protein expression are decreased in HCC tissues and several cell lines when compared to adjacent tumor‐free tissues and normal liver cell lines, as determined by qRT‐PCR and Western blot. Here, WWOX is linked to carcinoma.