The WW domain, which contains two conserved tryptophan residues, is a protein‐interaction domain.9 In a large number of signaling pathways, the WW domain was reported to exist in Yes‐associated protein (YAP), Rsp‐5, and other signaling and regulatory proteins.9, 10 Being located on chromosome 16q23‐24 with possible spanning fragile sites like FRA16D, WW domain‐containing oxidoreductase (WWOX) has been considered as a tumor suppressor in many types of carcinomas.11, 12 This gene encodes a member of the short‐chain dehydrogenases/reductases (SDR) protein family. The gene discussed is WWOX; the disease is carcinoma.