CD8A and neoplasm: Finally, when a cell-associated antigen was provided exogenously, supernatants from co-cultures with these pro-inflammatory DCs and allogeneic PBMCs promoted a highly efficient cross-presentation in bystander MoDCs (more than 10-fold increase when compared to non-treated immature MoDCs) of cell-associated tumor antigens to antigen-specific, IFN-γ producing CD8+ T cells [45].