Injection of pro-inflammatory allogeneic DCs into a site (subcutaneous tissue or melanoma tumor) transfected with a virus vector, inducing local expression of the tumor antigen gp-100, resulted in the generation of gp-100 specific CD8+ T cells and when combined with transfer of gp100-specific pmel-1 T cells, a prolonged survival of B16-F10 melanoma-bearing mice was observed [47]. This evidence concerns the gene CD8A and neoplasm.