In a second study, oligodendrocyte progenitor cells (Olig2+/Sox2+/APC−) were identified as the most proliferative population in the postnatal pons and thus likely cells of origin as proliferating cells are more likely to acquire new mutations during cell division than non-dividing cells, initiating DIPG pathogenesis (28). This evidence concerns the gene OLIG2 and diffuse intrinsic pontine glioma.