MAPT and Alzheimer disease: Treatment of 12-month-old 3xTg-AD mice for 3 months with the GSK-3 inhibitor, LiCl, was shown to reduce phosphorylation of tau at Thr 181, Ser 202/Thr 205, Thr 231, and Thr 212/Ser 214, but not Ser 396/40438.