RORγ1 regulated tumor-promoting “emergency” granulo-monocytopoiesis by suppressing negative (Socs3 and Bcl3) and promoting positive (C/EBPb) regulators of granulopoiesis and RORγ1 promoted expansion of tumor-promoting MDSCs and TAM in fibrocarcinoma mice models (65). This evidence concerns the gene BCL3 and neoplasm.