Manifestations associated with renal vasculature involvement in the presence of persistently positive aPL and/or APS include renal artery or vein thrombosis, thrombotic microangiopathy lesions in lupus nephritis biopsies, allograft thrombosis after kidney transplantation, and a small-vessel nephropathy characterized as APS nephropathy with variable outcomes. Here, FASLG is linked to thrombotic microangiopathy.