The results obtained shown that only Tol-DCs (vitD3) derived from RRMS patients, induced hyporesponsiveness in autologous antigen-specific T-cells restricted to myelin-derived peptides and produced higher levels of IL-10 and reduced levels of TNF-α compared to healthy controls, making the tolerogenic potential of these autologous Tol-DCs may be an effective tool to re-establish tolerance in RRMS patients and set up the basis for the ongoing clinical trials (62). The gene discussed is IL10; the disease is relapsing-remitting multiple sclerosis.