CASP3 and myocardial infarction: In a study by Chen et al., they determined Sca1+ CPC-derived exosomes are critical for cardiac repair by protecting against H2O2-induced H9C2 cardiomyocytes injury, which lead to approximately 53% reduction in cell apoptosis via inhibiting caspase-3/7 activation in a mouse model of acute MI/R (Chen et al., 2013).