Considering the influence of Rhes on the survival of nigrostriatal DAergic neurons (Pinna et al., 2016), and the differential incidence of PD between men and women (Gillies et al., 2014; Labandeira-Garcia et al., 2016), in the present study, we investigated the possible presence of neurotoxic and neuroinflammatory events in male and female Rhes KO mice at different ages. Here, RASD2 is linked to Parkinson disease.