Furthermore, in vitro and in vivo evidence has revealed that the calcium channel dysregulation may be linked to a number of disorders, including PD; in this regard, it has been found that Rhes influences a specific type of calcium channel, the N-type/Cav2.2, reducing the basal calcium current density and thereby influencing calcium-dependent events, such as α-synuclein aggregation (Thapliyal et al., 2008; Sciamanna et al., 2015). Here, CACNA1B is linked to Parkinson disease.