In conclusion, as suggested in our previous article (Pinna et al., 2016), Rhes KO mice might represent a genetic model of a mild PD-like phenotype and the results reported in the present study may give further support to Rhes KO mice as a suitable model to study mechanisms and vulnerability factors of DAergic neurons degeneration as in PD. The gene discussed is RASD2; the disease is Parkinson disease.