According to our current results of increased ReHo at the bilateral insula, bilateral thalamus, left putamen, and right S1 following acupuncture at SP6 in PMS patients, we speculate that the widely increased synchronization of neuronal activity in the sensorimotor cortical network may be due to altered sensory transduction pathways in the brain induced by SP6. This evidence concerns the gene SP6 and premenstrual tension.