TARDBP and amyotrophic lateral sclerosis: Although our Drosophila model is based on TDP-43 overexpression, it remarkably predicts molecular alterations in ALS spinal cords (Coyne et al., 2014) or patient derived motor neurons (Coyne et al., 2017), as well as confirms the limited neuroprotective potential of pioglitazone as a therapeutic for ALS (Joardar et al., 2014).