TARDBP and amyotrophic lateral sclerosis: Here we investigated metabolic changes in a Drosophila model of ALS that recapitulates key features of the human disease including the presence of insoluble TDP-43 complexes, synaptic deficits, locomotor dysfunction and reduced lifespan (Estes et al., 2011, 2013; Coyne et al., 2014, 2017).