Besides rotenone, JNK is also involved in the neurodegeneration of other PD models, such as MPTP, 6-hydroxydopamine, and dopamine, indicating that JNK is involved in neurotoxin-induced neurodegenerative processes in PD pathogenesis (Wang et al., 2004; Crocker et al., 2011; Zhang et al., 2016). The gene discussed is MAPK8; the disease is Parkinson disease.