Our data show that in a non-Pavlovian anxiety-related setting, CRH-dependent modulation of BLA−CE connectivity was mediated by presynaptic effects (Figs. 3e, f,, 4c), which might, in part, synergize with CRH-driven postsynaptic facilitation of BLA inputs to CEl SOM+ cells [9]. This evidence concerns the gene CRH and Anxiety.