Here, we demonstrate that G6PD levels are altered in liver cancer patients from The Cancer Genome Atlas (http://cancergenome.nih.gov/), its mRNA levels increase in conjunction with rise tumor grade, and its levels also negatively correlate with the expression of miR-122 and miR-1, a previously reported regulator of G6PD33,34. This evidence concerns the gene G6PD and neoplasm.