Since both miR-381-mediated posttranscriptional regulation of UBE2C and ALKBH5-induced epitranscriptional activation of UBE2C were identified as essential mechanisms governing upstream regulation of UBE2C in this study, the interaction of NCTD with those epigenetic and epitranscriptional modulators is one of pathways for NCTD-mediated specific repression of UBE2C and its downstream target genes in lung cancer. The gene discussed is ALKBH5; the disease is lung carcinoma.