miR-381, as the post-transcriptional repressor of UBE2C, is downregulated and co-exists with UBE2C activation in NSCLC, which is further validated followed by our results that showed that overexpressing miR-381 with its mimics significantly reduced the UBE2C expression in lung cancer cells (Fig. 8a). This evidence concerns the gene UBE2C and lung cancer.