As revealed in Supplementary Figure S1F, reactivation of E-cadherin and repression of vimentin induced by UBE2C deficiency were partially blocked with specific inhibition of ATG3 and LC3 in NSCLC, which suggests that UBE2C-mediated repression of autophagy is involved in execution of EMT and the consequent invasive growth of tumor cells. The gene discussed is VIM; the disease is neoplasm.