Ubiquitin-conjugating enzyme E2C (UBE2C), one of ubiquitination enzymes catalyzing degradation of proteins into smaller polypeptides, amino acids, and ubiquitins in 26S proteasome4,5, is involved in carcinogenesis via regulating cell cycle, apoptosis, and transcriptional process6–8, in which UBE2C was upregulated and correlated with poorer overall survival (OS) and progression-free survival of NSCLC patients7. This evidence concerns the gene UBE2C and non-small cell lung carcinoma.