Since the deregulated UBE2C-autophagy repression axis is one of complicated signal transduction pathways involved in the progression of lung cancer and varieties of direct downstream targets of UBE2C have been identified in driving tumor cell proliferation and invasion recently10, we need to further explore how UBE2C-ATG3/LC3B axis affects critical downstream target genes involved in cell proliferation and invasion. The gene discussed is UBE2C; the disease is lung carcinoma.