Genetic mutations in either WNK1 or WNK4 cause the autosomal dominant hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII) via NCC activation, and the phenotype of PHAII is opposite of that of Gitelman syndrome, which is caused by loss of function of NCC11,12. This evidence concerns the gene WNK4 and pseudohypoaldosteronism type 2.