It is interesting that the heat shock cognate 70–2 (hsc70) was enriched in 5 KEGG pathways (corrected p-value < 0.05): influenza a (ko05164); legionellosis (ko05134); estrogen signaling pathway (ko04915); measles (ko05162); antigen processing and presentation (ko04612), indicate that hsc70 plays a comprehensive role in the acute thermal stress response, a result that has been shown in different species4,37,38. The gene discussed is HSPA8; the disease is influenza.