Moreover, a detailed survey of immunohistochemical staining of human cancers indicated that SRPK1, KIF3B, C14orf142, NR2F1, and TMEM229B have significantly increased expression in the invasive zone of the primary tumors of these cancers as delineated by a pathologist (Supplementary Fig. 9b–g). The gene discussed is TMEM229B; the disease is cancer.