TMEM229B and malignant colon neoplasm: Indeed, our analysis indicated that the top hit genes identified in our screen are significantly upregulated in the metastatic lesions of several solid cancer types including: melanoma (KIF3B, C14orf142, and NR2F1), prostate cancer (SRPK1 and KIF3B), head and neck cancer (KIF3B), lung cancer (SRPK1 and TMEM229B), ovarian cancer (NR2F1) and colon cancer (NR2F1) (Supplementary Fig. 9a).