Indeed, our analysis indicated that the top hit genes identified in our screen are significantly upregulated in the metastatic lesions of several solid cancer types including: melanoma (KIF3B, C14orf142, and NR2F1), prostate cancer (SRPK1 and KIF3B), head and neck cancer (KIF3B), lung cancer (SRPK1 and TMEM229B), ovarian cancer (NR2F1) and colon cancer (NR2F1) (Supplementary Fig. 9a). This evidence concerns the gene TMEM229B and Familial prostate cancer.