Considering the possibility that the observed motility phenotypes could be specific to the highly metastatic human HEp3 epidermoid-carcinoma cell line, we evaluated the silencing of our top targets KIF3B, SRPK1, and NR2F1 using MAts in vitro cell migration model using HEp3, HT1080, MDA231, and PC3 human cancer cell lines. Here, SRPK1 is linked to squamous cell carcinoma.