FUS and amyotrophic lateral sclerosis: This is likewise the case for two other ALS disease proteins, the RNA-binding protein transactive response DNA binding protein of 43 kDa (TDP-43) [114] and fused in sarcoma (FUS) [115], which is secreted via exosomes, with the former also transmitted between neurons across axon terminals [116] as well as via TNTs [117].