Supporting the role of WBC, a more recent study [40] found that the combination of plasma levels of high sensitive (hs) CRP (3 mg/L), fibrinogen (14 μMol/L) and WBC count (9 × 109/L) were associated with increased risk of exacerbations in COPD patients, regardless of the disease severity and the exacerbation history. Here, CRP is linked to chronic obstructive pulmonary disease.