Another author found in COPD subjects who had chest X-rays at the time of hospitalization for AECOPD that NT-proBNP was a good indicator of radiological parameters related to cardiac dysfunction and/or volume overload such as cardiac size, pulmonary edema, and pleural effusion with AUCs of 0.72, 0.63, and 0.64, respectively [67]. The gene discussed is NPPB; the disease is Pleural effusion.