Other groups developed similar models with mutations in Ink4/Arf (also known as Cdkn2a), Muc1, Mist1 (also known as Bhlha15), Smad4 and Tgfbr2 tumor suppressors (Aguirre et al., 2003; Tinder et al., 2008; Tuveson et al., 2006; Kojima et al., 2007; Ijichi et al., 2006). Here, BHLHA15 is linked to neoplasm.