Histologically, orthotopic tumors treated with FOLIRINOX displayed significantly greater amounts of the apoptotic marker, cleaved caspase-3, as measured by the percentage of positive cells (16.6±4.5% vs 3.4±1.9%, P<0.0001), consistent with tumor cell death and decreased tumor volume (Fig. 6D). This evidence concerns the gene CASP3 and neoplasm.