Once infiltrated in the liver, soluble factors derived from pancreatic cancer cells, for example colony stimulating factor-1 (CSF-1) [136], trigger MAMs to produce and secrete granulin, a glycoprotein previously implicated in the wound healing response and breast cancer as a potent activator of stromal fibroblasts [137, 138]. This evidence concerns the gene CSF1 and pancreatic neoplasm.