A similar role for COX-2 overexpression in PDAC seems plausible, as it has been reported that downregulation of COX-2 expression represses tumor cell invasiveness and motility in various pancreatic cancer cell lines and reduces the number of liver metastases in an orthotopic mouse model of PDAC [53, 54]. This evidence concerns the gene PTGS2 and familial pancreatic carcinoma.