Pancreatic cancer cells co-cultured with human PSCs (hPSCs) assume a fibroblastic morphology, and exhibit transcriptional downregulation of the epithelial markers E-cadherin and cytokeratin 19 and upregulation of the mesenchymal markers vimentin and Snai1, concomitant with a marked increase in pancreatic cancer cell motility [47]. The gene discussed is VIM; the disease is familial pancreatic carcinoma.