Pancreatic cancer patients with distant metastatic disease were found to have higher levels of circulating glypican-1 (GPC1)+ exosomes than those with regional or no metastasis, and a substantial decrease in GPC1+ exosomes in the serum of PDAC patients following resection could predict improved overall and disease-specific survival [130]. Here, GPC1 is linked to familial pancreatic carcinoma.