Rather, this section aims to provide a detailed understanding of how tumor-secreted factors in PDAC contribute to the metastatic success of disseminated pancreatic cancer cells by transforming the liver into a hospitable niche (Fig. 1), with a focus on tissue factor (TF), tissue inhibitor of metalloproteinases-1 (TIMP-1) and exosomes. The gene discussed is TIMP1; the disease is familial pancreatic carcinoma.