The expression of both HE4 and CA125 from ovarian cancer ascites supernatant correlated positively with serum CA125 in the no chemotherapy group, and the differences were significant (p < 0.001, Fig. 4a, b); however, the differences were not significant in the chemotherapy group (p > 0.05, Fig. 4d, e). Here, WFDC2 is linked to ovarian carcinoma.