PTK2 and colorectal carcinoma: After quantification, significantly positive correlations were observed between SNCG and activated β1 integrin (Fig. 5e, r = 0.524; p = 0.001), SNCG and p-FAK (Y397) (Fig. 5f, r = 0.336; p = 0.042), and activated β1 integrin and p-FAK (Y397) (Fig. 5g, r = 0.733; p = 0.0001), confirming the existence of SNCG-β1-FAK pathway in CRC tissues.