Soluble membrane-type 5 matrix metalloproteinase (MT5-MMP/MMP-24) was identified as a significantly upregulated protein by SNCG treatment (fold change = 2.22), which was validated in the supernatants of CRC cell lines (Fig. 6b, Additional file 1: Figure S4A). The gene discussed is MMP24; the disease is colorectal carcinoma.