Other ongoing vaccination trials are testing an immunodominant HER-2 peptide (nelipepimut-S, also known as E75) in combination with granulocyte-macrophage colony stimulating factor either in a neoadjuvant setting against DCIS (ClinicalTrials.gov NCT02636582) or to prevent the development of metastases after conventional therapy in more advanced, node-positive patients (ClinicalTrials.gov NCT01479244). The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.