Recent mouse studies reveal that apolipoprotein E (ApoE) enhances miR-146a expression in monocytes and macrophages, suppressing NF-κB-mediated inflammation and atherosclerosis, and that systemic delivery of miR-146a mimetic attenuates monocyte/macrophage activation and atherosclerosis in the absence of plasma lipid reduction [18]. This evidence concerns the gene APOE and atherosclerosis.