A role for miR-146a in atherosclerosis is suggested by its ability to negatively regulate several pro-inflammatory factors that promote disease progression, including Toll-like receptor 4 (TLR4), IL-1 receptor-associated kinase 1 (IRAK1), and TNF receptor-associated protein factor 6 (TRAF6) [15,16]. The gene discussed is TRAF6; the disease is atherosclerosis.