Of note, Cheng et al. recently showed no differences in atherosclerosis burden in the aortic arch of Ldlr-/- mice transplanted with BM miR-146a-/-and fed HFD for 4 weeks; however, they found a significant decrease in plaque burden in BM miR-146a-/-Ldlr-/- mice after 12 weeks of HFD [22]. Here, LDLR is linked to atherosclerosis.