The malaria naïve controls showed no reactivity to any of the antigens tested (Fig 4, top row and S4 Fig) (SERA3 ag1 OD = 0.124; SERA3 ag2 OD = 0.131; SSP2/TRAP OD = 0.117; TSERA2 ag1 OD = 0.118). The gene discussed is CD40LG; the disease is malaria.