TARDBP and amyotrophic lateral sclerosis: In this study, mSOD1 mice (which reflects the pathogenic mechanisms of SOD1 ALS, whereas the majority of ALS presents TDP43 UBIs) were treated with 2 mg/kg body weight/d, a dosage >50 times higher than that used in clinical practice (usually 2 mg/d), which gives blood concentrations that have well known toxic effects.