MTOR and amyotrophic lateral sclerosis: Rapamycin has been tested in several neurodegeneration models because it is an mTOR-dependent autophagy activator, and accelerates the removal of abnormal accumulation of aggregated proteins [9,10] with beneficial effects.[7] Rapamycin administration exerted a beneficial effect in several cell lines,[9,11–13] and in several ALS animal models, improving motor and cognitive phenotype.[14–18]