IL4 and amyotrophic lateral sclerosis: As for the role of immunity in ALS, recent studies suggest that innate and adaptive immune systems contribute to ALS progression: Msod1 Tregs cocultured with activated Msod1 microglia attenuated the expression of microglial toxic factors by IL4 release, and promoted MN survival by suppressing M1 activation, inducing an M2 protective phenotype, and reducing the release of ROS.