Vascular endothelial growth factor-positive patients may benefit more from bevacizumab treatment.[24] Previous studies have shown that the time interval between diagnosis of the primary tumor and manifestation of gastrointestinal metastasis ranged between 2 week and 4 years and the mean time between the identification of the gastrointestinal metastasis and mortality was 100.6 days.[18,25] Because of the poor survival of the majority of patients, the early diagnosis and the development of novel systemic therapies for gastrointestinal metastasis of lung cancer are of paramount importance. Here, VEGFA is linked to lung cancer.