TFE3 and clear cell renal carcinoma: While the proportion of renal cell carcinoma in adults was only 1% to 1.6%.[2] According to the reports of Argani et al, Xp11.2-RCC resulted from the fusion of TFE3 gene with 1 of 5 different genes, including ASPL (17q25), PRCC (1q21), PSF (1q34), NonO (Xq12) and CLTC (17q23).[3,4] The main clinical manifestations of this type of renal cell carcinoma include hematuria and lumbago, and also frequently occur in the clear cell renal cell carcinoma patients.