In addition to acid ceramidase, other proteins (as previously described) including tripeptidyl-peptidase 1 and APOD were present in high amounts in the samples and have been also reported as major components of lipofuscin-like lysosomal inclusion bodies.71 APOD is involved in binding and transport of lipids,72 in their protection from oxidation and consequent oxidative stress.73 APOD is consistently upregulated and highly expressed during normal aging,74 in overall SN tissue of PD patients75 and other neurodegenerative diseases,72 where oxidative stress and lipid abnormalities are implicated. This evidence concerns the gene TPP1 and neurodegenerative disease.