Some of the most frequently seen side effects include neuropathic pain (52%), fever (39%), infection (39%), hypokalemia (35%), hypersensitivity reaction (25%), capillary leak syndrome (23%), hyponatremia (23%), transaminitis (elevated alanine transaminase [ALT] 23%; elevated aspartate transaminase [AST] 10%), gastrointestinal side effects (nausea, vomiting, diarrhea; 22%), hypotension (18%), hypoxia (13%), and urticaria (13%; Yu et al., 2010). This evidence concerns the gene GPT and Hyponatremia.