The pathway associated with the most cancer types (17) was “extracellular vesicle mediated signaling in recipient cells”, which contains cancer causing genes including WNT, EGFR, RAF, NRAS, and KRAS, and is upstream of pivotal cancer pathways.43 Other pathways associated with high numbers of cancers were the “RAC1 PAC1 P38 MMP2 pathway” containing MAPK, ERK, KRAS, RAC, RAS genes and “copper homeostatis” which has been found to be relevant to multiple tumor types and is being trialed as a chemotherapy target.44 This evidence concerns the gene AKT1 and neoplasm.