In a 72-year-old woman with no associated personal or family history of breast and/or ovarian cancers, we identified a novel somatic pathogenic <i>BRCA2</i> variant (<i>c.18_28delAGAGAGGCCAA</i>, p.Lys6Asnfs*4) using next-generation sequencing (NGS). The gene discussed is BRCA2; the disease is ovarian carcinoma.