TF and metastatic neoplasm: As all patients who presented a thrombotic event during the follow-up period had a metastatic tumor at diagnosis, same analysis was performed in the subgroup of PDAC patients with metastasis (Supplementary Figure 2), the association between elevated D-dimers, MV-TF activity or CA 19-9 with VTE was not significant anymore (HR, 3.5; 95% CI, 0.8–38.8; p = 0.08; HR, 1.0; 95% CI, 0.2–4.8; p = 1.0 and HR, 2.5; 95% CI, 0.5–11.4; p = 0.2; respectively).