Compared to IPMN and to CP patients, PDAC patients had significant higher levels of fibrinogen (p < 0.0001 and p = 0.01), interleukin-6 (p < 0.0001 and p = 0.009), factor VIII (p = 0.0003 and p < 0.0001), D-dimers (p < 0.0001 and p = 0.0001), VWF (p < 0.0001 and p < 0.0001), free TFPI (p < 0.0001 and p < 0.0001) and extracellular DNA (p < 0.0001 and p < 0.0001). This evidence concerns the gene TFPI and pancreatic intraductal papillary-mucinous neoplasm.