SOCE regulates the main cancer processes such as apoptosis, proliferation and migration/invasion in tumors from epithelial origin [27, 63, 64] through modification of Ca2+ dependent pathways such as NFAT, Calmoduline (CaM) and its kinase (CaMK), and/or nuclear factor-kappa B (NFκB) (for review: [27, 65, 66]). The gene discussed is NFKB1; the disease is cancer.