KRAS2–4/NRAS2–4/BRAF15 genotype was evaluated in 67 tumoral samples of 87 MCRC patients treated with FIr-B/FOx first line treatment (77%) (Table 1): 58 (86.6%) primary tumours, 9 (13.4%) metastatic sites (3 liver, 2 peritoneal carcinomatosis, 2 ovary, 1 local recurrence, and 1 lymph node); 60 (89.6%) obtained before first line metastatic treatment, 7 (10.4%) after first line treatment. This evidence concerns the gene KRAS and neoplasm.