CDKN2A and lung carcinoma: Indeed, lung carcinomas with elevated levels of UHRF1 develop the capacity to bypass cell contact inhibition; a typical feature observed in human lung fibroblasts that is associated with hypermethylation of cyclin-dependent kinase Inhibitor 2A (CDKN2A) and Ras association domain-containing protein 1 (RASSF1) promoters.