The specimens of the other two EGFR-mutant cases (9%) were classified on biopsies as most likely adenosquamous carcinomas (ADSC), based on the co-existence of cells with mucin production, keratinization and ADC/SCC immunohistochemical markers (CK7+/TTF1+/CK5+/p40+). This evidence concerns the gene SERPINB3 and adenosquamous carcinoma.