Other mutations were identified in CTNNB1 (n=2, 13%), KRAS, FGFR1, FGFR3, MET, SMAD4, PIK3CA, NRAS, DDR2, ERBB4 (all n=1, 7%), with the latter 3 gene-mutations concomitantly present in the same tumor (patient 15, Table 2). This evidence concerns the gene SMAD4 and neoplasm.