To this purpose, cryopreserved PB samples from 7 U-CLL and 5 M-CLL CLL cases were tested for multiple conditions using 2 additional backbone stimulations previously reported as effective in improving CLL proliferation and survival, besides CpG+IL2 [13, 14], namely sCD40L+CpG [11] and sCD40L+IL21 [12], along with the NE pooled from PB of CLL samples and HS (Table 1). The gene discussed is IL21; the disease is B-cell chronic lymphocytic leukemia.