High nuclear GPER expression was significantly associated with smaller tumours (χ2=22.5; d.f.=1; P<0.001), lower tumour grade (χ2=23.6; d.f.=2; P<0.001), lower NPI value (χ2=22.0; d.f.=2; P<0.001), ER positive tumours (χ2=4.8; d.f.=1; P=0.029); and with tumour stage (χ2=7.5; d.f.=2; P=0.024) (Table 1). The gene discussed is GPER1; the disease is neoplasm.