Our results show that restoration of TET2 expression in glioblastoma cells tends to upregulate genes involved in neural differentiation including the Brain fatty acid-binding protein (BFABP), implicated in glial lineage differentiation [56], the proneural basic helix–loop–helix (bHLH) transcription factor Mash1, related to oligodendrogenesis and neural precursor differentiation [57–61] and Cystathionine β-Synthase (cbs), whose protein expression is detected at high levels in astrocytes [62]. This evidence concerns the gene ASCL1 and glioblastoma.