Based on these results, we hypothesize Fap1 influences the biology of malignant stem cells in a tissue agnostic manner in neoplasms as diverse as CRC and CML, and might be a rationale therapeutic target to prevent relapse, and/or effect cure, in a number of cancers. The gene discussed is PTPN13; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.