ITGA2B and glioblastoma: Specific fibrinogen-binding, which was determined as difference between fibrinogen binding alone and in the presence of tirofibane as surrogate marker for GPIIB/IIIa activation, was tentatively increased in GBM (GBM: median 8.7 MFI, range from −50.1 MFI to 56.5 MFI/CON: median −8.6 MFI, range from −64.8 MFI to 13.9 MFI/p = 0.1), but did not reach statistical significance (Figure 1C).