CD63 expression which is classically associated with delta-granule secretion [10] was significantly increased after TRAP stimulation in GBM patients (GBM: median 38.4%, range from 11% to 62.5%/CON: 33.3%, range from 15.5% to 64.4%/p = 0.04) (Figure 3A). The gene discussed is CD63; the disease is glioblastoma.