By analyses of ‘The Cancer Genome Atlas’ datasets, PLK1 expression levels were found to be significantly higher in P53-mutated than in P53–wild-type cancers [56], which also correlates to the observation that the FoxM1 transcription factor network that regulates PLK1 expression was found to be upregulated in 87% of patients with HGSOC [57]. This evidence concerns the gene FOXM1 and cancer.