This observation together with the established clinical relevance of fascin [23, 56] and our findings that the PCAIs diminish the levels of fascin protein in the H1299 NSCLC in a concentration-dependent manner, suggest that the PCAIs may alter the levels of fascin mRNA and/or the stability of this protein to suppress its function in filopodia formation. The gene discussed is FSCN1; the disease is non-small cell lung carcinoma.